The histopathology of hydroa vacciniforme-like lymphoma can resemble other aggressive cutaneous T-cell lymphomas, so recognizing the clinical characteristics is important.
Patients with Epstein-Barr virus (EBV) infection may develop a lymphoproliferative disorder (LPD) that clinically mimics hydroa vacciniforme (HV), a chronic photosensitivity reaction characterized by erythema, vesicular papules, bullae, and ulcers leading to scar formation. HV-like lymphoma (HVL) is one variant, a rare and aggressive cutaneous T-cell lymphoma occurring mainly in children in Latin America and Asia. These authors retrospectively studied clinical outcomes in 12 Bolivian patients (mean age, 14 years; only 1 adult) with HVL.
The clinical presentation included painful recurrent vesicles, papules, and plaques with a crust and hemorrhagic center in both sun-exposed and non-exposed areas. Central facial edema, especially around the m…
Reviewing Author
DisclosuresGrant / Research support NIH/NCI, The Plastic Surgery Foundation
DisclosuresGrant / Research support NIH/NCI, The Plastic Surgery Foundation