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The uricosuric agent probenecid is indicated in gout patients who require urate-lowering therapy, underexcrete uric acid, and are intolerant of allopurinol. In this retrospective study from a rheumatology clinic in New Zealand, researchers describe their experience with this drug.
Of 521 gout patients in this clinic, 57 were treated with probenecid. About half the probenecid recipients took the drug because they did not tolerate allopurinol; in these patients, probenecid lowered the mean serum uric acid level from 9.8 mg/dL to 6.9 mg/dL. In the remaining cases, the drug was added to allopurinol (because of inadequate response to allopurinol monotherapy). In these patients, allopurinol lowered the mean serum uric acid level from 10.6 mg/dL to…