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Hepatitis C virus (HCV)–related cirrhosis is a leading cause of liver-related morbidity and mortality. Identifying prognostic biomarkers of long-term outcomes might allow clinicians to risk-stratify their patients with cirrhosis and target high-risk patients for closer, more-intensive monitoring. In the current study, investigators assessed whether a 186-gene signature from liver tissue can predict death, progression of cirrhosis, or hepatocellular carcinoma (HCC) in HCV-infected patients with cirrhosis.
Researchers performed whole-genome gene expression profiling on archived liver biopsy tissue of 216 HCV-infected patients with Child-Pugh Class A cirrhosis (identified only by histology). The patients had been enrolled in a long-term, cohort…