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During the last year, more than 740 patients have developed fungal meningitis, spinal or paraspinal infections, or other complications following injections of contaminated methylprednisolone prepared by one Massachusetts compounding pharmacy. Fungal meningitis was seen early in the outbreak; spinal and paraspinal infections have occurred later, sometimes many months after the implicated injections. Because early recognition and treatment should be beneficial, researchers in Michigan developed a magnetic resonance imaging (MRI) screening protocol that was offered to recipients of one lot of contaminated methylprednisolone used at a single pain-treatment center.
Between November 2012 and April 2013, screening spinal MRI studies were performed …