Updating specifics of the low but significant risks for disease-specific metastasis and death
The authors of a 10-year retrospective cohort study of cutaneous squamous cell carcinoma (cSCC) treated at Brigham and Women's Hospital in Boston reviewed 985 patients and 1982 tumors to identify risk factors independently associated with poor outcomes.
In a median follow-up of 50 months, these patients had a 2.1% risk for disease-specific death and a 3.7% risk for metastasis. Risk factors associated with elevated risk included tumor diameter >2 cm, invasion into fat, perineural invasion, poor histologic differentiation, and location on the ear, temple, or anogenital area. The size of the cohort precluded separate computation of the risk for poor outcomes in immunosuppressed or transplant patients. Similarly, tumor depth could not be evaluat…
Reviewing Author
DisclosuresConsultant / Advisory boardAmway
Editorial boards JAMA Dermatology; Dermatologic Surgery; Journal of Cosmetic Dermatology; Lasers in Medical Science; Skin Therapy Letter
Leadership positions in professional societies American Academy of Dermatology (Chair, Health Care Finance Committee); American College of Mohs Surgery (Board of Directors); American Society for Dermatologic Surgery (Board of Directors)
DisclosuresConsultant / Advisory boardAmway
Editorial boards JAMA Dermatology; Dermatologic Surgery; Journal of Cosmetic Dermatology; Lasers in Medical Science; Skin Therapy Letter
Leadership positions in professional societies American Academy of Dermatology (Chair, Health Care Finance Committee); American College of Mohs Surgery (Board of Directors); American Society for Dermatologic Surgery (Board of Directors)