Effect of Pneumococcal Vaccination on U.S. Hospitalization Rates

Despite concerns about “replacement” disease, reduced hospitalization rates for pneumonia have been sustained for a decade following introduction of the 7-valent conjugate vaccine.

Addition of the 7-valent pneumococcal vaccine (PCV7) to the childhood immunization schedule in 2000 has dramatically reduced the incidence of invasive pneumococcal disease across all age groups. To determine whether “replacement” disease caused by nonvaccine serotypes has eroded some of the gains achieved by PCV7, investigators evaluated hospitalization rates for pneumonia among children and adults.

Data from the Nationwide Inpatient Sample were examined for three periods: 1997–1999 (pre-PCV7); 2001–2006 (early PCV7); and 2007–2009 (late PCV7). The year 2000 was excluded because it was considered a transition period. Records were analyzed for patients with a first-listed discharge diagnosis of pneumonia, or a first-listed discharge diagnosis…

Reviewing Author

Larry M. Baddour, MD

Disclosures

RoyaltiesUpToDate, Inc. (Authorship duties)

Larry M. Baddour, MD

Disclosures

RoyaltiesUpToDate, Inc. (Authorship duties)

Effect of Pneumococcal Vaccination on U.S. Hospitalization Rates

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Reviewing Author