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Renal disease is the most important long-term sequela of the common childhood vasculitis, Henoch-Schönlein purpura (HSP). In a multicenter, double-blinded, randomized, placebo-controlled trial, investigators evaluated the treatment effects of intravenous prednisolone (2 mg/kg for 7 days followed by 1 mg/kg for 7 days) in 352 children (age <18 years) with new-onset HSP.
After 12 months, the proportion of children in the prednisolone and placebo groups with elevated urine protein concentrations (15% and 10%) or hematuria alone (5% and 4%) did not differ significantly. The presence of proteinuria also did not differ between groups after adjusting for baseline proteinuria or treatment for hypertension. Five patients (4 placebo recipients) requir…