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In August 2013, the U.S. Public Health Service updated its national guidelines for occupational postexposure prophylaxis (PEP). Authored by an expert panel, these guidelines replace the previous version, which dates back to 2005.
Key recommendations include the following:
Clinicians may use any validated testing options, including point-of-care rapid tests, for evaluating the HIV status of the source patient. Initiation of PEP should not be delayed while waiting for test results.
There is no need to rule out the “window period” in the source patient unless acute HIV infection is suspected clinically.
The PEP regimen of choice is tenofovir/FTC plus raltegravir for 4 weeks. Many alternative regimens are listed, including the single-pill tenofovir…