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Researchers at a hospital in Canada evaluated the records of patients taking warfarin who had international normalized ratios ≥1.5 and required reversal for bleeding or emergency procedures. Outcomes were compared for 149 patients who received fresh frozen plasma (FFP) during the 2 years before the hospital switched to 4-factor prothrombin complex (Octaplex) as the therapy of choice, and 165 patients who received prothrombin complex during the 2 years after the switch. Atrial fibrillation was the most common indication for warfarin. Patients with intracranial bleeding received a 1500-IU dose of prothrombin complex, whereas those with other bleeding sites received a 1000-IU dose.
Time to reversal was significantly shorter in the prothrombin c…