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Several small studies have suggested an association between calcium-channel blocker (CCB) use and excess risk for breast cancer; other studies, particularly those with short follow-up, have shown no relation. To understand these conflicting results, investigators identified 1907 women (age range, 55–74) with breast cancer (invasive ductal or invasive lobular carcinomas) from a surveillance registry; cases were age-matched to 856 controls without breast cancer from a community population. Breast cancer patients were more likely to have family histories of breast cancer, be current alcohol users and smokers, and be current users of combined estrogen-progestin hormone therapy.
After adjustment for potentially confounding clinical and demographi…