Increasing the Effectiveness of Ovarian Cancer Screening

Two-stage approach based on changes in CA125 could minimize unnecessary surgery.

Screening for ovarian cancer using a single cut point (e.g., ≥35 U/mL) for cancer antigen (CA) 125 yields low positive predictive values (PPVs), indicating that this approach is not effective (NEJM JW Womens Health Jun 16 2011). Now, investigators have serially screened postmenopausal women using the Risk of Ovarian Cancer Algorithm (ROCA) — which takes into account changes in CA125 levels over time — along with transvaginal sonography (TVS). When ROCA scores indicated normal risk for ovarian cancer, women were advised to undergo repeat CA125 assessment in 1 year. Women with intermediate risk were advised to repeat CA125 assessment in 3 months. High-risk women were advised to undergo TVS and were referred to a gynecologic oncologist.

Among 4…

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Increasing the Effectiveness of Ovarian Cancer Screening

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Reviewing Author