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Since the Lauren system of classifying gastric cancer was developed in 1965, the disease has been defined according to histologic features as either intestinal or diffuse. Can genetic data about gastric tumors provide additional information to inform therapy? To find out, investigators in Singapore identified the genetic expression of 248 gastric-tumor cell lines using microarray data from consensus hierarchical clustering with iterative feature selection.
The gene-expression profiles suggested three subtypes of gastric tumors — proliferative, metabolic, and mesenchymal — each with distinct genomic and epigenomic properties. The subtypes were validated in profiles of 70 tumors from Australian patients. Drug sensitivities of each type were ba…