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Antidepressants may lead to increased bone loss, but the several studies on this topic have had cross-sectional designs or prospective designs with many years between assessments. The current research group used 10 years of data gathered annually on 1972 middle-aged menstruating women (baseline age range, 42–52) from the Study of Women's Health Across the Nation to examine possible associations between new use of selective serotonin reuptake inhibitors (311 women) or tricyclic antidepressants (71 women) and subsequent changes in bone mineral density (BMD) at hip, femoral neck, and lumbar spine.
BMD decreased less than 1% annually, and decreases were similar in antidepressant users and the 1590 nonusers. The results were unchanged after contr…