Benefit of Oral Bovine Immunoglobulin for HIV Enteropathy

In a small, 8-week, open-label pilot study, twice-daily oral bovine immunoglobulin improved symptoms and some measures of gut immune function.

The profound effect of HIV infection on the immune function of the gut is believed to be one of the key factors underlying persistent immune activation and dysfunction despite highly suppressive antiretroviral therapy (ART). Severe cases of HIV-induced gut dysfunction can manifest as HIV enteropathy (i.e., chronic gut symptoms — frequent loose stools — in HIV-infected individuals on ART, without an identifiable, reversible cause).

In a recent open-label pilot study that was partially funded by the manufacturer, eight patients with HIV enteropathy were given oral serum-derived bovine immunoglobulin twice daily for 8 weeks. The patients were men (median age, 44.5) who had been on ART for >1 year, with consistently undetectable viral loads; the…

Reviewing Authors

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Jason Baker, MD

Benefit of Oral Bovine Immunoglobulin for HIV Enteropathy

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Reviewing Authors