Risk Factors for Cardiac Transplantation in Children with Hypertrophic Cardiomyopathy

Children diagnosed with idiopathic disease after 1 year of age have excellent outcomes.

Hypertrophic cardiomyopathy (HC) often leads to heart failure and the need for cardiac transplantation. To determine risk factors for HC in children, researchers evaluated data for 958 children diagnosed with HC from 1990 to 2009 in 98 U.S. centers.

Risk for death or transplantation at 2 years were as follows: 18% of 788 children with pure (isolated) HC, 41% of 69 with mixed HC with dilatation, and 41% of 58 with mixed HC and restrictive or other cardiomyopathy. Risk for death or transplantation was only 3% at 2 years for children with idiopathic disease diagnosed after age 1 year. Risk factors for poor outcomes were age <1 year, low body weight, congestive heart failure, left ventricular (LV) fractional shortening, high LV end-diastolic pos…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Risk Factors for Cardiac Transplantation in Children with Hypertrophic Cardiomyopathy

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Reviewing Author