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The first randomized, controlled trial of fecal occult blood testing (FOBT) for colorectal cancer (originally published in 1993) — and perhaps the first convincing evidence that colorectal cancer screening works (a single case-control study of sigmoidoscopy had been published the previous year) — came from the Minnesota Colon Cancer Control Study. In this trial, 46,551 healthy participants were randomized to undergo no screening (usual care) or annual or biennial guaiac-based FOBT with rehydrated slides. Previously reported findings from this trial include reductions in mortality from colorectal cancer in the screened group, as well as a reduction in incidence, attributed to higher rates of colonoscopy and polypectomy in the screened groups…