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Patients with inflammatory bowel disease (IBD) often ask about alternative therapies or report using them. To assess the current evidence on the efficacy of herbal therapies in treating ulcerative colitis (UC) and Crohn disease (CD), investigators conducted a systematic review.
Of 1094 abstracts identified, researchers selected 21 randomized, controlled trials for review (14 in UC and 7 in CD) involving a total of 1484 patients.
Studies showing positive findings for herbal therapies compared with placebo in UC included:
A 4-week comparison of active treatment with wheat grass juice (Triticum aestivum) in 23 patients with active distal UC (response, 91% vs. 42%)
An 8-week trial of Andrographis paniculata extract (HMPL-004; 1800 mg daily) in 224 …