Noninvasive Respiratory Support Reduces Bronchopulmonary Dysplasia in Preterm infants

A meta-analysis of four trials indicates that early nasal CPAP is superior to intubation as primary respiratory support.

Noninvasive respiratory support modalities such as nasal continuous positive airway pressure (CPAP) have been widely adopted in the management of preterm infants to reduce lung injury and improve outcomes. However, even large randomized studies have generally not shown clear-cut reductions in death or bronchopulmonary dysplasia. These authors conducted a meta-analysis of data from four randomized controlled trials (2782 infants) that compared nasal CPAP and endotracheal intubation as the primary mode of respiratory support after birth in preterm infants (<32 weeks' gestation). All four trials reported outcomes of death or bronchopulmonary dysplasia (defined as the need for oxygen support or mechanical ventilation at 36 weeks' corrected gest…

Reviewing Author

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Noninvasive Respiratory Support Reduces Bronchopulmonary Dysplasia in Preterm infants

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Reviewing Author