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Patients with heart failure (HF) are at excess risk for mortality, from both cardiac- and noncardiac-related causes. In this case-control study from a large community database in Minnesota, investigators sought to assess the relation between HF and cancer (and the effect of cancer on prognosis) in 961 newly diagnosed HF patients and the same number of community-based controls matched for age and sex. The prevalence of cancer at HF-diagnosis index date was similar (22% of HF patients and 23% of controls); 596 pairs in which neither member had cancer at the index date were followed for incident cancer and survival.
During an average follow-up of 7.7 years, risk for incident cancer was significantly higher in HF patients (hazard ratio, 1.68) af…