An analysis supports the suppositions long held by treating clinicians.
After basal cell carcinomas, cutaneous squamous cell carcinomas (SCCs) are the most common malignancies in Caucasians. Incidence continues to increase, and in certain populations, such as organ transplant recipients on immunosuppressive therapy, the risk for metastasis and death is substantial. Treatment options for SCCs include surgery, radiation, cryotherapy, and photodynamic therapy (PDT), but, surprisingly, no randomized, controlled trials have assessed the efficacy of these interventions. These authors analyzed 118 published observational studies and case reports that assessed the management of nonmetastatic, invasive SCCs of the skin to ascertain the efficacy of different treatments.
In 12 studies that evaluated surgical excision, the …
Reviewing Author
DisclosuresConsultant / Advisory board Astellas Pharmaceuticals
EquityVaxin
Grant / Research support NIH; NIH/NCI; Veteran’s Administration; Ferndale Laboratories; Kyowa Hakko Kirin Pharma, Inc.
Editorial boards Cancer Prevention Research; Photodermatology, Photoimmunology, & Photomedicine; UpToDate; eMedicine; Journal of Dermatological Sciences; JAMA Dermatology
Leadership positions in professional societies American Academy of Dermatology (Vice Chair, Committee on Science and Research); Photomedicine Society (Board of Directors)
DisclosuresConsultant / Advisory board Astellas Pharmaceuticals
EquityVaxin
Grant / Research support NIH; NIH/NCI; Veteran’s Administration; Ferndale Laboratories; Kyowa Hakko Kirin Pharma, Inc.
Editorial boards Cancer Prevention Research; Photodermatology, Photoimmunology, & Photomedicine; UpToDate; eMedicine; Journal of Dermatological Sciences; JAMA Dermatology
Leadership positions in professional societies American Academy of Dermatology (Vice Chair, Committee on Science and Research); Photomedicine Society (Board of Directors)