A Promising Interferon-Free Regimen for HCV Genotype 1 Infection

In a phase II trial, a single-tablet, all-oral regimen of sofosbuvir and ledipasvir achieved nearly 100% sustained virologic response in both treatment-naive and treatment-experienced patients.

The FDA should soon approve the interferon-based regimen of sofosbuvir plus peginterferon and ribavirin for the treatment of hepatitis C virus (HCV) genotype 1 infection. Response rates of 90% have been achieved with only 12 weeks of therapy in treatment-naive patients without cirrhosis. The next step in the evolution of therapies for HCV genotype 1 infection is the development of interferon-free regimens.

In this phase II, open-label, randomized trial, investigators evaluated sofosbuvir (a nucleotide polymerase inhibitor; 400 mg) plus ledipasvir (an HCV NS5A inhibitor; 90 mg) in a single combination tablet taken daily with or without ribavirin (1000–1200 mg daily). In one cohort, 60 treatment-naive patients without cirrhosis were randomized…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

A Promising Interferon-Free Regimen for HCV Genotype 1 Infection

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Reviewing Author