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It's time again for me to choose the most important stories of the year — this year, as NEJM Journal Watch Gastroenterology. We remain devoted to providing clinicians with the information they need to give their patients the best care — and, as part of NEJM Group, we are now poised to do that better than ever. This year, I focused on stories that informed changes in my own practice. Here's a brief overview.
In inflammatory bowel disease, the issues I found most important were loss of response to tumor necrosis factor α agents and its prevention with adjunctive immunomodulator therapy, as well as management of loss of response based on blood testing for serum levels and antibodies.
In colonoscopy, further documentation of its effectiveness in …