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Impaired connectivity between limbic and frontal cortices in people diagnosed with depression or post-traumatic stress disorder is well documented, but little neuroimaging of connectivity has been done in an adolescent, nonpatient sample. To learn more, investigators enrolled 64 adolescents from a community-based, longitudinal study on the basis of consent and proximity to the neuroimaging facility. Annually, from ages 15 to 18, participants completed trauma and emotional health scales; at age 18, they underwent resting-state functional magnetic resonance imaging of the amygdala and hippocampal pathways involved in depression.
Decrements in connectivity between the hippocampus and subgenual anterior cingulate cortex (sgACC) were significantl…