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Traumatic brain injury (TBI) increases risk for subsequent mood disorders in adults, but the relation in adolescents is uncertain. Investigators used a Taiwanese health insurance database to compare ICD-9 diagnoses of mood disorders between patients (age range, 10–24 years) who had two outpatient or one inpatient claim for TBI in 2000–2004 and age- and sex-matched controls with non–TBI-related claims in the same year. Patients with preexisting mood disorders were excluded.
Among 15,000 patients with TBI (58% male; 58% aged 10–19 years) and 76,000 randomly chosen controls, 3.0% and 1.5%, respectively, developed a mood disorder within 5 years. Risk for mood disorder within 5 years in the TBI group remained doubled after adjustment for demograp…