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Although conventional karyotyping following chorionic villus sampling or amniocentesis has long been standard analysis, this approach cannot detect submicroscopic abnormalities such as DNA deletions and duplications. Chromosomal microarray analysis can identify these copy number variants by comparing hybridization of fetal DNA with that of DNA sequences of known identities. Recent results of a large NIH-sponsored study of karyotyping compared with chromosomal microarray analysis showed that microarray detected clinically meaningful abnormalities in 6% of fetuses with ultrasonically detected structural abn…