Paget Disease and Malignancy

Extramammary Paget disease patients have increased risk for secondary malignancies, and the initial site of disease predicts the site of the secondary malignancies.

Most patients with Paget disease of the breast have an underlying breast adenocarcinoma. Invasive or noninvasive, extramammary Paget disease (EMPD) may be associated with synchronous occult malignancy, which may or may not be contiguous. These tumors can be removed if detected. Invasive EMPD usually involves the vulva, anus, scrotum, penis, or axillae; synchronous malignancy is also possible in these cases. To assess the risk for a second related malignancy, investigators used the SEER database to identify 1439 patients with invasive EMPD (median age at diagnosis, 71 years; 965 women) and age- and sex-matched unaffected controls. The investigators then searched the database for subsequent primary invasive cancers diagnosed more than 12 mont…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)

Paget Disease and Malignancy

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Reviewing Author