Eosinophilic Esophagitis Might Progress from Inflammatory to Fibrostenotic Disease

The optimal type and duration of treatment for eosinophilic esophagitis (EoE) remain unknown. In particular, the need for and effect of chronic or maintenance therapy in preventing long-term complications is unclear. However, multiple phenotypes of EoE have been described and might represent different clinical variants, possibly influencing treatment and outcomes. In the current retrospective analysis, investigators from a single tertiary center described clinical features of 374 patients with different endoscopic phenotypes of EoE.

Mean age at diagnosis was 25 years (range, 0.5–82 years). Endoscopic phenotypes were fibrostenotic (marked by esophageal rings, narrowing, or stricture without linear furrows or white plaques), inflammatory (mark…