Acute Kidney Injury Predicts Mortality in Cirrhosis with Infection

This newly redefined indicator successfully identified patients at higher risk for organ failure and mortality among a group hospitalized with bacterial infections.

Renal function is a strong prognostic marker in patients with cirrhosis. Even small increases in creatinine in this population can reflect renal dysfunction. Recently, acute kidney injury (AKI) in patients with cirrhosis was redefined using a lower threshold for renal dysfunction (increase in serum creatinine level of ≥0.3 mg/dL in <48 hours or a 50% increase in creatinine from a stable baseline). Now, investigators have prospectively evaluated whether the new AKI definition is useful in predicting outcomes in a high-risk group of patients with cirrhosis: those hospitalized with bacterial infection.

Among 337 patients in 12 participating centers, 166 fulfilled criteria for AKI. After adjustment for the Model for End-Stage Liver Disease score…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Acute Kidney Injury Predicts Mortality in Cirrhosis with Infection

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Reviewing Author