Head Trauma and Amyloid Deposition

History of head trauma is associated with markers of Alzheimer disease in elders with mild cognitive impairment but not in those with normal cognition.

Studies associating a history of head trauma with increased risk and earlier age of onset for Alzheimer disease (AD) have yielded contradictory results. Now, researchers have conducted a population-based study of 448 cognitively normal (CN) elders (aged 70 and older) and 141 elders with mild cognitive impairment (MCI) who underwent neuroimaging measures of structure (brain magnetic resonance imaging of hippocampal volumes), function (brain fluorodeoxyglucose positron emission tomography [FDG-PET]), and neuropathology (amyloid-PET).

In the CN group, 17% self-reported head trauma associated with loss of consciousness or memory impairment; 18% of the MCI group self-reported such head trauma. In the CN group, none of the neuroimaging measures di…

Reviewing Author

Brandy R. Matthews, MD

Disclosures

Grant / Research supportNational Institute on Aging

Brandy R. Matthews, MD

Disclosures

Grant / Research supportNational Institute on Aging

Head Trauma and Amyloid Deposition

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Reviewing Author