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Preeclampsia, late pregnancy loss, placental abruption, and small-for-gestational-age (SGA) babies are associated with thrombosis of placental vessels and placental infarction. These placental-mediated complications often recur in subsequent pregnancies, but whether these recurrences can be prevented by treatment with antithrombotic agents is unclear.
To examine the effectiveness of prophylactic low-molecular-weight heparin (LMWH) with or without aspirin versus no LMWH with or without aspirin in this setting, an international team of investigators performed a systemic review and meta-analysis of 6 randomized trials encompassing 848 pregnant women with prior placenta-mediated pregnancy complications.
The primary outcome of any recurrent preecl…