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Family history of hepatocellular carcinoma (HCC) has been reported as a risk factor for HCC in patients with hepatitis B virus (HBV) infection. However, the magnitude of the risk has not been well characterized.
The current study is a sub-study of a prospective, community-based cohort study (the REVEAL study) that examined the risk factors for HCC in 22,472 participants with and without viral hepatitis in 7 townships in Taiwan. Patients underwent routine visits and were followed for a mean of 16 years. HCC was identified through the national cancer registry.
During 362,268 person-years of follow-up, 374 cases of HCC were identified. Among hepatitis B surface antigen (HBsAg)–negative patients, the cumulative risk for HCC was similar between pa…