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Technological advances in freezing human eggs have improved the likelihood of pregnancy success to the point that such procedures should no longer be considered experimental. In a Committee Opinion, the American College of Obstetricians and Gynecologists expands on previous guidelines published jointly with the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology (Fertil Steril 2013; 99:37). Oocyte cryopreservation should be offered to women aged ≤35 as an alternative to cryopreserving embryos before treatment with chemotherapeutic drugs or pelvic radiotherapy for cancer. In addition, women with genetic conditions (e.g., fragile X premutation, mosaicism for monosomy X) that predispose them to prema…