Prognostic Influence of CIN3 History and Age

The long-term risk for incident cervical or vaginal cancer following treatment for cervical intraepithelial neoplasia grade 3 (CIN3) remains largely unknown. Using medical and death records for all Swedish women from 1958 to 2008, investigators assessed incidence of cancer and death in women with and without prior, treated CIN3.

Risk for cervical or vaginal cancer was 2.4 times higher in the >150,000 women treated for CIN3 than in the general female population. Risk for death from cervical or vaginal cancer was also 2.4-fold higher in the CIN3 population. Among women treated for CIN3 at age ≥60, risk for cervical or vaginal cancer was especially high (11- to 29-fold higher than among all women, and rising with each decade). Higher risk for c…