NF-κ Bleach

Very dilute solutions of hypochlorite decreased the severity of dermatitis in mice.

Bathing in dilute bleach solutions (0.005% v/v hypochlorite [HOCL]) effectively reduces colonization of bacteria and helps the skin heal. A new study shows topical HOCL 0.005% inhibits the proinflammatory pathway NF-κB and ameliorates NF-κB–mediated skin diseases in mice.

HOCL reversibly inhibited the expression of CCL2 and SOD2, NF-κB-dependent genes, in primary human keratinocyte cultures. HOCL also inhibited the activity of NF-κB kinase, a major regulator of NF-κB activation. In the skin of mice, topical HOCL reduced stimulated NF-κB signaling. In an acute radiation dermatitis model, topical HOCL inhibited expression of NF-κB-dependent genes, decreased the severity of dermatitis, and prevented skin ulceration. Skin of aged HOCL-treated mi…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)