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Many options exist for noninvasive testing in patients with suspected coronary artery disease. In this multicenter registry study, U.S. investigators tracked outcomes and costs in 1703 patients without known coronary disease who underwent coronary computed tomography angiography (CTA; 590 patients) or nuclear myocardial perfusion imaging (with either positron-emission tomography [PET; 548 patients] or single-photon–emission computed tomography [SPECT; 565 patients]).
During 2 years of follow-up, mean costs were highest after PET (US$6647), intermediate after CTA ($4909), and lowest after SPECT ($3965). After propensity-score adjustment for differences among groups, costs for CTA and PET were 15% higher and 22% higher, respectively, than for …