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Several studies have shown that vitamins C and E impair glucose regulation (NEJM JW Psychiatry Jun 8 2009) and raise risk for Alzheimer disease (NEJM JW Psychiatry Apr 23 2012). Here is another study to relate to our patients who believe that these antioxidant vitamins “can't hurt.”
In a double-blind study partially funded by supplement manufacturers, 54 individuals (28 women; mean age, 24) were randomized to receive placebo or vitamin C (1000 mg/day) plus vitamin E (DL-alpha-tocopherol acetate, 235 mg/day) while they participated in an 11-week endurance training program. The two groups did not differ in change in performance over time (VO2max, submaximal running, and a shuttle run test). However, only the placebo group showed improvement at…