High-Frequency Ventilation Improves Long-Term Lung Function in Preterm Babies

Improvements in lung function were observed in adolescents treated with high-frequency oscillatory ventilation after extremely premature birth.

Numerous randomized trials have explored the use of high-frequency oscillatory ventilation (HFOV) for respiratory failure associated with prematurity. Meta-analyses of the results have shown either no effect or modest reductions in bronchopulmonary dysplasia with HFOV versus conventional ventilation (NEJM JW Pediatr Adolesc Med Jun 23 2010). To date, few studies have examined long-term outcomes.

Now, researchers report on the lung function of children (age range, 11–14) who were randomized to early use of HFOV or conventional ventilation after extremely preterm birth (<29 weeks' gestation). Of 797 infants originally randomized, 592 survived to hospital discharge, and short-term pulmonary outcomes (oxygen dependence at 36 weeks' corrected ges…

Reviewing Author

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

Robin Steinhorn, MD

Disclosures

Consultant/Advisory BoardActelion Pharmaceuticals

Editorial BoardsJournal of Pediatrics

Leadership Positions in Professional SocietiesAmerican Pediatric Society (President); American Board of Pediatrics (Board of Directors)

High-Frequency Ventilation Improves Long-Term Lung Function in Preterm Babies

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Reviewing Author