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Clinicians have little beyond diagnosis to guide their prescription of medication for psychiatric disorders; finding genetic predictors of response to treatment would substantially improve clinical practice. Using data from a large clinical trial of patients with social anxiety disorder (known to have low rates of response and remission to initial treatment with selective serotonin reuptake inhibitors [SSRIs]), researchers examined variants in four genes linked either to anxious temperament (RGS2 and genes for the serotonin 2A receptor and the norepinephrine transporter) or to SSRI treatment response (serotonin transporter promoter [5-HTTLPR]).
The 346 participants with genotyping data received 10 weeks of open-label, manufacturer-supplied s…