Does Helicobacter pylori Eradication Improve Functional Dyspepsia?

Functional dyspepsia is a common disorder with heterogeneous etiologies. Multiple studies have evaluated the effect of Helicobacter pylori eradication on functional dyspepsia symptoms with variable results. Now, investigators in China have conducted a meta-analysis of the issue using data from randomized, controlled trials.

The meta-analysis included high-quality studies (Jadad score >3) that assessed the effect of H. pylori eradication therapy on the severity of functional dyspepsia symptoms, included at least 12 months of follow-up, and were published in English.

Fourteen studies met inclusion criteria and comprised 2993 patients. Although only four studies suggested a benefit of H. pylori treatment, a pooled analysis of all study data show…