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Standard therapies for Helicobacter pylori infection have decreasing effectiveness because of increasing drug resistance. Tetracycline is a common component of different H. pylori treatment regimens, but doxycycline may have potential therapeutic advantages of better tissue penetration and less frequent dosing. In an effort to identify a potential therapy for patients with multidrug-resistant H. pylori infection, investigators in Portugal prospectively studied the efficacy of a proton-pump inhibitor (PPI), amoxicillin, and doxycycline regimen.
The study comprised 16 patients (13 women, 3 men) with known resistance to clarithromycin, metronidazole, and levofloxacin but susceptibility to amoxicillin and tetracycline based on cultures of endosc…