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Although not a primary drug for treatment of methicillin-susceptible Staphylococcus aureus (MSSA) infections, ceftriaxone has pharmacologic properties that make it attractive for use when such infections require long-term therapy. In 2012, the Clinical and Laboratory Standards Institute recommended using oxacillin, cefoxitin, penicillin, and ceftaroline to determine antimicrobial susceptibility of MSSA isolates, under the assumption that other β-lactam antibiotics will have equivalent activity. In the literature, the reported ceftriaxone resistance rate for MSSA is <3%.
In a recent retrospective, observational study conducted at a community hospital in Pittsburgh, isolates from patients with MSSA bacteremia between January 2012 and February …