Decreasing Mortality from Sepsis

A review of intensive care unit admissions in Australia and New Zealand shows a marked decrease in mortality from severe sepsis.

The last decade has seen numerous changes in the management of severe sepsis, including the tracking of serum lactate levels, aggressive fluid resuscitation, and prompt initiation of effective antibiotic therapy. However, the clinical effects of these measures have not been well defined. To address this issue, researchers used the Australian and New Zealand Intensive Care Society adult intensive care unit (ICU) patient database to analyze hospital outcomes of patients admitted with severe sepsis to any of 171 ICUs between 2000 and 2012.

Among 1,037,115 patients treated in these ICUs during the 13-year study period, 101,064 (9.7%) had severe sepsis. The proportion of ICU patients with severe sepsis progressively increased, from 7.2% in 2000 t…

Reviewing Author

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Richard T. Ellison III, MD

Disclosures

Consult/Advisory BoardAcurx Pharmaceuticals, LLC;

Grant/Research SupportDoctors Company Foundation, Massachusetts Department of Public Health

Decreasing Mortality from Sepsis

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Reviewing Author