Gestational Trophoblastic Neoplasia Can Occur After Molar Pregnancies Despite Undetectable HCG

Moreover, cytotoxic therapy for hydatidiform mole does not prevent GTN.

Excess risk for gestational trophoblastic neoplasia (GTN) can follow any molar pregnancy, but especially in patients who are older at pregnancy and have histories of molar recurrence. GTN can occur even after circulating human chorionic gonadotropin (hCG) levels are no longer detectable, and clinicians in Senegal sought to determine the magnitude of this risk in a retrospective review of national data from 2006 through 2012. Levels of hCG were measured with a two-site monoclonal antibody immunoradiometric assay, with levels <5 IU/mL considered undetectable. A total of 531 women with molar pregnancies were included; low-risk patients were followed with periodic hCG determinations, medium-risk patients received single-agent chemotherapy (meth…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Gestational Trophoblastic Neoplasia Can Occur After Molar Pregnancies Despite Undetectable HCG

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Reviewing Author