Overdiagnosis of Barrett Esophagus

Upon systematic re-evaluation of 130 patients, one third had their previous diagnosis of BE reversed.

Prevalence estimates of Barrett esophagus (BE) vary; an early estimate was 12% among patients who experienced heartburn >3 times per week, but subsequent rates have ranged from 1% to 25%. One challenge to the validity of BE diagnosis has been variable interpretation of endoscopic findings.

To assess the accuracy of BE diagnoses, three investigators received didactic and endoscopic consensus training and re-evaluated 130 patients who had been previously diagnosed with BE. A standard biopsy protocol was used, with pathology reviewed by an expert gastrointestinal pathologist. In a lead-in phase, each investigator performed endoscopies in 10 patients, and photographs, videotapes, and histologic evidence were reviewed by the other two investigato…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors