Triclosan-Coated Sutures Ineffective in Reducing Surgical-Site Infections

In a large, multicenter trial, using triclosan-coated sutures instead of standard ones for fascia closure after open abdominal surgery did not reduce postoperative surgical-site infections.

Surgical-site infections are common after abdominal surgery, occurring in 12% to 16% of patients undergoing midline laparotomy. In the manufacturer-supported, multicenter, randomized PROUD (Prevention of Abdominal Wound Infection) trial, researchers compared infection rates between triclosan-coated sutures and noncoated ones. Triclosan interferes with microbial lipid synthesis, which confers broad antibacterial activity.

At 24 hospitals in Germany, adults undergoing elective midline abdominal laparotomy were randomized to triclosan-coated polydioxanone (PDS Plus) or standard polydioxanone (PDS II) sutures for fascia closure. Surgeons, patients, and outcome assessors were blinded to group assignment. Assessment for wound infection was done on…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Triclosan-Coated Sutures Ineffective in Reducing Surgical-Site Infections

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Reviewing Author