As antiretroviral regimens become more potent and better tolerated, virologic outcomes have improved; regimen simplification has also helped by decreasing pill burden and increasing adherence.
The success of antiretroviral therapy (ART) is directly correlated with adherence, which in turn depends on the convenience and tolerability of the regimens involved. In recent years, ART regimens have become simpler, with lower pill burdens and once-daily dosing.
To evaluate the effects of these changes on ART adherence and virologic suppression, investigators conducted a meta-analysis of relevant randomized, controlled trials published in the literature or presented at conferences in abstract form. Nineteen studies (totaling 6321 adult patients) published between 2004 and 2011 met the inclusion criteria: 11 (totaling 3092 patients) that had been published in a previous meta-analysis (NEJM JW AIDS Clin Care Feb 9 2009) plus 8 additional one…
Reviewing Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)