Tadalafil Might Ease Symptoms of Benign Prostatic Hyperplasia

This drug, widely used for erectile dysfunction, improved urinary flow rates modestly in patients with BPH.

Phosphodiesterase-5 inhibitors are known mainly for treating erectile dysfunction, but one of them — tadalafil (Cialis) — also is FDA-approved for treating patients with symptomatic benign prostatic hyperplasia (BPH); the mechanism of action for mitigating BPH is unclear.

In this analysis of pooled data from four previously published randomized trials, industry-supported researchers present outcomes in about 1200 men with moderate-to-severe BPH who received daily tadalafil (5 mg) or placebo for 12 weeks. The 35-point International Prostate Symptom Score (I-PSS) improved by an average of about 2 points more with tadalafil than with placebo, which is a significant difference. Additionally, from a mean baseline maximum urinary flow rate of abou…

Reviewing Author

Allan S. Brett, MD

Disclosures

Nothing to disclose

Allan S. Brett, MD

Disclosures

Nothing to disclose

Tadalafil Might Ease Symptoms of Benign Prostatic Hyperplasia

Topics

Reviewing Author