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A meta-analysis of randomized trials showed no clinical benefit from glucosamine in patients with knee or hip osteoarthritis (OA; NEJM JW Gen Med Oct 7 2010). Nevertheless, many patients take glucosamine, and some clinicians encourage its use because a few small studies suggested potential benefit and because no adverse effects are apparent. In this latest study, researchers (supported by the manufacturer of Regenasure glucosamine hydrochloride evaluated the effect of their product on joint structure (as assessed by magnetic resonance imaging [MRI]) and cartilage degradation (as assessed by the biomarker urinary C-terminal crosslinking telopeptide of type II collagen [CTX-II]).
Two hundred one adults (mean age, 52) with mild-to-moderate knee…