Loading...
Bacteria are widely suspected to be one of the inciting antigens in ulcerative colitis (UC). As such, antibiotics, probiotics, and fecal microbiota transplantation have all been established or proposed as treatments for UC.
In the current open-label, multicenter trial, researchers assessed the efficacy of a combination of amoxicillin (500 mg), tetracycline (500 mg), and metronidazole (250 mg) 3 times daily for 2 weeks to induce and maintain remission in patients refractory to or dependent on steroids. The same researchers had previously designed this regimen to treat elevated levels of Fusobacterium varium observed in inflamed colonic mucosa of patients with ulcerative colitis and serum antibodies to F. varium. The regimen was effective for …