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The Rockall scoring system identifies the risk of rebleeding from peptic ulcers. Standard therapy for patients with high-risk endoscopic stigmata is endoscopic therapy plus high-dose, intravenous proton pump-inhibitor (PPI) treatment for 3 days, followed by an oral PPI. Patients with a Rockall score ≥6 have an elevated risk for rebleeding after the 3 days of intravenous therapy. Now, investigators in Taiwan have evaluated the impact of higher oral PPI doses on 28-day rebleeding risk in high-risk patients.
A total of 293 patients with high-risk endoscopic stigmata were treated endoscopically and then received 3 days of high-dose PPI therapy. One hundred and eighty-seven patients with a Rockall score ≥6 without subsequent bleeding on day 3 wer…